Friday 30 December 2011

Can a pill cure hangovers?

Stock photo of a woman with a hangover

Blowfish tablets claim to cure hangover symptoms. But doctors say that masking the pain may make things worse.
For those who plan to celebrate the New Year with a few toasts but aren't looking forward to the inevitable hangover, a new pill on the market may resolve the dread of the day after.
Tablets called Blowfish have recently been permitted by the US Food and Drug Administration (FDA) to be sold as an over-the-counter drug. Their creator guarantees their effectiveness in chasing away the post-booze blues.
Nevertheless, some in the medical field remain sceptical, warning that such pills should not be seen as a licence to overdo the drinking.
Brenna Haysom, founder and president of Rally Labs, the company which creates Blowfish, told that the development of the remedy came out of her own experience.
"I was a hangover sufferer," she says. "I worked hard in finance, many times into the weekend, and needed to function well the next day while still enjoying my free time."
Simple formula
Ms Haysom says she tried different hangover remedies on the market to no effect.
She then decided to delve into the causes and effects of hangovers, experimenting with different combinations of ingredients, first on herself and then on her friends.
"After a lot of trial and error I realised that I was on to something: a reliable, effective hangover cure," she says.
Man holds an empty beer bottle and sleepsOn January 1, revellers are prepared to feel pain
It's easy to imagine that this "cure" would contain secret ingredients mixed in a complicated formula, but this entrepreneur admits that her anti-hangover pills are "nothing special".
They are basically a blend of high doses of aspirin and caffeine packed in effervescent tablets that dissolve in water, to drink in the morning. The two ingredients work together to fight fatigue and pain, two main complaints of hangover sufferers.
It also contains a little something sweet to help the medicine go down.
"We spent a lot of time on flavouring to make it palatable," she says.
Blowfish is not the first treatment aimed at hangover sufferers.
"Every year there is a new product out that claims to be the cure against hangovers," says Richard Blondell, vice-chair for Addiction Medicine at the American Academy of Family Physicians.
"Blowfish is simply this year's thing," he says.
'Marketing scheme'
Indeed, products like HangoverBuster, Alcohol-X and Chaser Plus have been on the market for years, all promising fantastic results.
Blowfish, however, is the only hangover medication to receive FDA acknowledgement, since it uses drugs approved by that agency.
Other hangover remedies use herbal supplements, which are unregulated by the FDA.
As none of the components of Blowfish are new, the FDA process was not as stringent as it would have been for an original drug.

The science of a hangover

What causes a hangover is still not fully understood, and can vary from person to person. Here are some medical explanations for what might make us feel so bad:
  • Chemical imbalance: Alcohol suppresses the release of an anti-diuretic hormone, which causes us to expel more fluid instead of conserving it. The result is dehydration which leads to fatigue, lethargy, dizziness and headache.
  • Hypoglycaemia: Alcohol may also result in a rise and drop in sugar levels, which can contribute to shakiness and fatigue.
  • Congeners: Scientists debate whether impurities in alcohol called congeners contribute to feeling ill. Darker alcohol has more congeners, and research has shown consumption of dark alcohol leads to a bigger hangover than lighter alcohol, though function is similarly impaired with both.
  • Acid secretion Alcohol relaxes the region of the stomach that controls acid reflux, which could lead to an irritated feeling in the gut.
Source: Dr Aaron White, NIAAA
Instead, the agency determined that the product was compliant with the FDA's over-the-counter monograph process. That ensures that products are made of previously approved substances, include safe doses and are properly labelled.
The FDA concluded that Blowfish was not misleading consumers by promoting itself as a hangover aid.
Dr Blondell, who advises that not getting drunk is the best and only real cure for hangovers, doubts the effectiveness of most treatments.
"They are a good marketing scheme," he says.
More importantly, the tablets can't undo the damage done by a hard night on the town, which can include strain on the liver, poor nutritional choices and embarrassing Facebook photographs.
"It's like saying to an obese person to eat all they want because there is a pill that will cure heartburn, but the calories are already inside."
Despite of such scepticism, Ms Haysom says that her product has had a "great response", with comments on the Blowfish Facebook page suggesting it has "saved Christmas."
Natural punishment
Is this treatment just a licence to drink in excess without having to pay the consequences later?
Hangovers function as a kind of punishment that keeps people from over-indulging too often, says Dr Aaron White, a neuro-scientist with the National Institute for Alcohol Abuse and Alcoholism.
Woman drinks wineHangovers are one of the most unpleasant side effects of drinking
Dr White says that teenage and young adult binge drinking is a serious problem in the US.
What prevents young people from bingeing even more is not wanting to feel so awful afterwards, he says, so a drug that could take care of that situation would be of concern.
"It may change their relationship with alcohol and have them drink more often," he concluded, though notes that there is no evidence to suggest that hangover remedies increase drinking.
Ms Haysom rejects any suggestion that her product promotes heavy drinking.
"We are not saying 'take our product and all will be fine'," she says. "Alcohol is a poison and you will get a hangover as your body reacts to it. What our tablets do is treat the symptoms."
How effectively it treats the symptoms is another matter. Part of the reason there's been no effective hangover cure to this point is that scientists don't fully understand what a hangover is.
"You'd think we know the answers," says Dr White. "We're still trying to figure that out."
What they do know is that the complicated causes of hangovers affect individuals differently - so there may be no "one" cure that fits all sufferers.
That, of course, won't stop some New Year revellers for looking for a quick fix to start 2012 hangover-free.

Could hypersonic flight become a reality?

Lapcat A2

When Concorde was decommissioned in 2003, supersonic air travel became a thing of the past. But work has begun on a passenger aircraft that could go further and faster - flying from Europe to Australia in four hours. Will it ever become a reality?
The European Space Agency's goal is to create a hypersonic passenger plane, one that flies more than five times faster than the speed of sound and six times faster than a standard airliner.
It's not the first time hypersonic flight has been attempted. In 1960, tests took place on the X-15 - half plane, half missile - which carried one pilot and flew for 90 seconds before its rocket fuel burnt out.
Its creators thought it would herald a new era of high-speed civil aviation but more than 50 years later, a hypersonic passenger plane has yet to be tested or even built.
Now a team led by the European Space Agency, known as Lapcat, are working on an aircraft called the A2, which could take up where the X-15 left off.

Mach numbers

  • Mach number is the speed of an aircraft relative to the speed of sound passing through the air
  • Mach 1 is the speed of sound - approximately 1,236 km/h, depending on various factors including temperature and altitude
  • Mach 2 is twice the speed of sound, Mach 3 is three times the speed of sound and so on
The technology involved in exceeding the speed of sound - Mach 1 - is extremely complex.
"Mach number is the key," says aerodynamics expert at Imperial College London, Paul Bruce.
"When you go below Mach 1 - so flying slower than the speed of sound - and then transition to above Mach 1, the flow of physics completely changes. When you go to Mach 5 or 6 the laws start changing once again."
At hypersonic speeds, gasses and metals behave very differently. Airliner engines that work at subsonic speeds - about Mach 0.85 or 913km per hour - won't work.
Neil Armstrong standing by the X-15Neil Armstrong, the first man to set foot on the moon, once piloted the X-15
A plane that will fly five times faster than the speed of sound also needs an engine that can take off at subsonic, boost to supersonic and cruise at hypersonic speeds.
Another problem is heat. When air moves over the plane's chassis at high speed, friction causes its temperature to rise very quickly - to over 1,000C, so the outer shell of the plane has to be built to withstand very high temperatures.
Engineers think they can overcome these problems, but it will take them decades to do so. The A2 is not expected to fly until 2040.
The ghost of Concorde also haunts the project. Concorde flew for 27 years but after an air crash investigation grounded it in 2000, its carriers British Airways and Air France realised they could generate more revenue by selling first and business class tickets on subsonic planes.
Tom Otley of Business Traveller magazine believes hypersonic flight could suffer the same fate because the demand for faster flights just isn't there.

Inside the A2's engine

Inside the A2's engine
Reaction Engines in Oxford have designed a hybrid engine that will use a turbojet, like Concorde's, to take-off and accelerate to supersonic speeds and then a rocket that will kick in, taking the aircraft to Mach 6 and above.
Sabre, as the engine is called, will run on liquid hydrogen.
It will burn the hydrogen by pulling air in from the atmosphere.
"Speed isn't everything, comfort and cost play a big part. If you ask people how fast aircraft fly they wouldn't have a clue, they don't care but they do know which one is the most economical, which one is the most comfortable and which is the quietest."
Even business travellers are willing to take indirect flights in order to save money, a study found last year.
Reaction Engines, part of the Lapcat consortium, says the cost of hypersonic flight would match that of current business class travel - but sceptics say this presupposes the discovery of a new, much cheaper, way to produce the A2's liquid hydrogen fuel.
At present, to create enough hydrogen to fly 10 hypersonic planes from the UK to Australia every day would use up to 20% of the UK's national grid, according to one calculation. And in the European Union, airlines will from 2012 be obliged to pay for each unit of carbon they emit.
Even if cheap liquid hydrogen does become available, aviation expert John Strickland questions whether high-speed flying will ever make sense for the airline industry - which traditionally subsidises economy seats with the profits made in business class.
"If you took those people off those subsonic flights then you throw into question the economics of those flights," he says.
"Somewhere along the line you would end up either cancelling the subsonic flights or struggling to get the right price levels even to make a hypersonic service financially viable."

How to test a hypersonic plane

Testing how metals withstand high speed is extremely difficult.
Subsonic planes are tested in wind tunnels, but to blow wind from a fan at hypersonic speed would require an immense amount of energy. Instead a team at Imperial College London have created a high-pressure gun that shoots air at a test material at high speeds.
They have milliseconds to capture the effect using high-speed photography and temperature sensors.
The Europe to Australia route, he says, has a predominantly friends and family profile. And when British Airways tried to run Concorde to the Far East via Bahrain, the service proved unprofitable and was cancelled.
The A2 will not be able to fly to New York, the world's busiest business-class route, as the distance is too short for it to reach the necessary altitude.
So far, the Lapcat II project has received €10m (£8.33m) in funding from the European Commission and private investors. In 2013, that funding will run out and the project's viability will be reviewed before it can continue.
Project co-ordinator Johan Steelant is confident that the A2 concept will bear fruit.
"In 2013 we will be able to demonstrate that the critical technology is no longer a blocking point," he says. "But of course there are different systems and subsystems that still need to be proven."
The European Commission wants to be a pioneer, showing the way forward for aviation in the second half of the century, Mr Steelant says.
But John Strickland remains doubtful.
"It's a big scientific and technological ambition," he says. "But in this current climate when governments don't have enough money to deal with every day to day challenge they are certainly not going to put it into hypothetical projects to build a hypersonic airline."

China: Tens of thousands of ruins 'disappear'

Terracotta army soldiers in Xian (file photo)

China says about 44,000 ancient ruins, temples and other cultural sites have disappeared.
That's the conclusion of the country's first heritage census for more than 20 years.
About a quarter of the sites that remain are in a poor state of repair.
Explaining the results, an official quoted by Chinese state media said many such sites were unprotected and had been demolished to make way for construction projects.
The census, carried out by China's State Administration of Cultural Heritage, recorded the registration of 700,000 heritage sites.
Liu Xiaohe, deputy director of the survey, told state media that economic construction was the most important reason for the damage to cultural relics.
In the worst-affected region, Shaanxi province, which is the home of the terracotta warriors, the statistics indicate that more than 3,500 cultural sites have vanished.
No specific buildings or monuments were named in the census.
Correspondents say that even the iconic Great Wall of China has been threatened by erosion and unauthorised development, as conservation rules are flouted by hikers and exploited by local villagers who charge their own admission fees.
Two years ago a Qin Dynasty part of the Great Wall was said to have been damaged by miners who knocked holes in it while prospecting for gold.

Thursday 29 December 2011

Will India embrace Rahul Gandhi?

Rahul Gandhi at a public meeting in India
Rahul Gandhi is seen by many as a future prime minister

Under pressure over corruption scandals and a slowing economy, many in India's Congress party are looking to Rahul Gandhi, fourth generation scion of the famous Nehru-Gandhi dynasty. He campaigned in Uttar Pradesh, which faces crucial polls early next year.
In a large public ground near the city of Kanpur in Uttar Pradesh state, thousands of people wait in anticipation.
The largely rural gathering has spent several hours braving the chilly winter temperature for a glimpse of the heir to one of the world's most powerful political dynasties.
Even as a local politician tries to keep them engaged, a cheer runs through the crowd as a white SUV makes its way into the ground, its wheels churning up dust.
Rahul Gandhi, the man they've all come to see, steps out surrounded almost instantly by bodyguards in black suits and dark glasses.
'Give us a chance'
The crowd breaks out into an applause as he steps up to address them from a stage a fair distance from them.
"The Congress government has always worked for your interests," he says.
"Farmers, workers, the dispossessed, the poorest of the poor. Give us a chance and you'll see the results."
Uttar Pradesh is India's most politically influential state, which sends the most members to parliament.

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Everything costs so much more... maybe he can change all that. If not, we'll simply vote for someone else”
Ram GopalRice farmer
Once a Congress stronghold, the party has lost ground to regional, socialist parties which are seen as more representative of lower castes, minorities and other disadvantaged groups who have been left out of India's economic progress.
This is one of several rallies that the young Gandhi is addressing as part of his campaign for vital local elections due next year as he tries to rebuild his party's base.
Many are willing to give him a chance.
"The Gandhi family has always been inclusive, appealing to all groups rather than any one," says one old man.
"We are tired of the current crop of leaders. We think he can help improve things for us."
As he heads off to his next stop, we join his convoy as it speeds through the dusty lanes of Uttar Pradesh.
Along the way, hundreds of people gather to wave and catch a glimpse. The Gandhis are political royalty in India and the urge to get up close is irresistible.
And he obliges, leaning out of his car to shake hands or even get out at impromptu pit stops.
Feudal country
It's this iconic status that has always delivered and that his party is now banking on.
"There is a certain association that the country has with this family," says Neerja Chowdhury, a political commentator.
Rahul GandhiMr Gandhi has travelled the countryside to connect with the poor
Three generations of the family have governed India, from the first prime minister, Jawaharlal Nehru, to his daughter Indira Gandhi and her son Rajiv.
So for many, it's natural to assume that Rahul will also follow in their footsteps.
"They're a pan-Indian recognised family. Very few political families today are in this position. They are committed to secular values and remember, this is still a very feudal country," says Ms Chowdhury.
It's not going to be that easy though for Rahul Gandhi. Unlike the last time when a Gandhi was at the helm, India has changed politically and economically.
Makur is just one of many villages in his campaign belt but typical of the area.
In the early morning winter mist, children play in the dirt as the villagers tend to their cattle - older members huddle around a fire trying to stay warm.
Even as India has progressed, social and economic disparities have widened - it is something he has to address if he is to win them over.
"We have so many problems," says Ram Gopal, a rice farmer in his fifties, who attended his latest rally.
"Everything costs so much more, we lack water, our villagers are in a terrible shape. Maybe he can change all that.
"If not, we'll simply vote for someone else," he adds.
Back on the campaign trail, Rahul Gandhi is still drawing the crowds.
Even though his sights are set on these local elections, many in his party and elsewhere want him to now take on a larger, national role - perhaps even the job of leading the world's largest democracy.
The question is whether he is ready for it, and whether India in turn is ready to embrace him.

Bangladesh's most famous hangman

Babul Miah in his village
Mr Miah is now trying to use his experiences to stop conflicts in his home village

It may seem an odd way to become famous, but Babul Miah has the honour of being Bangladesh's most well-known executioner.
Mr Miah was jailed for life for committing a murder but he was released early for hanging 17 people to death inside the prison, and also for his good conduct.
Mr Miah returned to his home village of Nagor in northern Bangladesh last year after spending 22 years in prison. Though Bangladesh has dozens of hangmen, Mr Miah is considered the most famous.
In Bangladesh all hangmen are prisoners or former convicts who have trained in jail for the job.
Mr Miah is trying to rebuild his life with his family and friends in this picturesque village dotted with ponds, paddy fields and bamboo trees.
He was 17 when he was sent to prison in 1989 for a murder in his village which he says he did not commit.
"I became a hangman against my will. During my prison term the jail authorities told me that if I became a hangman, they would take two months off my sentence for every execution.
"I wanted to get out of jail early, so I took up the offer," Mr Miah said while tending to his cattle.
New world

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Mussammat Kobita Akther, Babul Miah's wife
At first I was frightened... Later on I realised that he was simply doing his job in the jail ”
Mussammat Kobita AktherBabul Miah's wife
Bangladesh is one of the countries where convicted prisoners are still executed by hanging.
More than 400 people have been executed since the country's independence from Pakistan in 1971. Officials say more than 1,000 prisoners are on death row.
Mr Miah was released last year as part of a general amnesty to around 1,000 prisoners in an attempt to ease overcrowding in jails.
For Mr Miah his release after two decades was like a rebirth.
"I was overjoyed after my release. When I came through Dhaka, it looked like a new world to me. The city had changed completely.
"When I reached my village, it was also different. I could not recognize many people and they also could not recognize me," Mr Miah recounted.
Soon after returning to his village, Mr Miah got married to a local girl, Mussammat Kobita Akther. The couple are expecting a baby.
Without a regular job, Mr Miah makes his living by working in his brother's farm and looks after cattle.
Sometimes, he works as a day labourer in neighbouring villages. He earns about 5000 takas ($70/£41) a month.
"A lot of people promised that they would give me a job or some money to start a business. But nothing has materialised. The cost of living has gone up tremendously in the last 20 years.
"I am not sure how I will manage my family with my meagre earnings," said Mr Miah.
The entrance to Dhaka Central PrisonDhaka Central Prison is where Babul Miah learnt the hangman's craft
His wife said that initially she was a bit scared to live with someone who had hanged a number of people.
"I felt sad when I heard about his past and that he had hanged many people to death in prison. At first I was frightened.
"Later on I realised that he was innocent and that he was simply doing his job in the jail," Ms Akther said.
"Nowadays he talks a lot about our future. He wants to give our children a good education so that they do not face hardships like him."
Mental toughness
Mr Miah was given special training in prison in how to hang people. He was taught how to set up the stage and attach wooden planks and the main hanging rope.
"I was sad when I hanged a person for the first time. But it wasn't anything to do with me - the courts had rejected their appeals.
"You cannot do the job if you show emotion or if you are not mentally strong. I had only one thing in my mind. If I do this, my jail sentence will be reduced," Mr Miah recounted.
He said he never once faltered during his 12-year tenure as a hangman in Bangladeshi jails. Even a year after his release from the prison he vividly recounted the procedures.
"Once the condemned prisoner was brought on to the stage, one of us would put the noose around his neck. At that time the convict used to shiver in fear.
"Then I would wait for a signal from a senior jail official," Mr Miah remembered.
"When the clock struck one minute past midnight, the officer would drop a red cloth from his hand as a signal, then I would pull the lever.
Mr Miah's home villageMr Miah is now trying to live a normal life in his home village
"The planks would go down and the person would be hanged. A doctor would check and pronounce him dead after 15 minutes."
Media spotlight
Though Mr Miah said he regretted every time he hanged someone, he was proud of one incident.
In January 2010, he was asked to hang the killers of the country's founding father, Sheikh Mujibur Rahman.
Mr Miah executed five former army officers for their role in the assassination of the former president in 1975.
"On that day, I was very eager to hang them because they killed the greatest leader of our country. I hanged all five of the killers.
"If the killers were a hundred in number, I would have hanged them all, without any hesitation."
The hangings attracted nationwide attention and Mr Miah became an overnight celebrity after a local newspaper published his photograph.
A private television channel also attempted to make a programme based on his experiences in jail.
Mr Miah said life inside prisons in Bangladesh was close to hell. Overcrowding and lack of sanitation was a major problem and many prisoners suffered from skin diseases.
Bangladesh's founding father, Sheikh Mujibur RahmanMr Miah shot to fame after executing the killers of Bangladesh's founder, Sheikh Mujibur Rahman
Bangladesh's 67 jails hold around 75,000 prisoners, at least three times their capacity.
Activists say the jails are unhygienic, filthy and sometimes violent.
"People living outside don't know the conditions inside the prisons. We used to fight for clean water.
"There's violence, drugs and homosexuality. But the situation has improved slightly in recent years."
Mr Miah said he would not wish a jail life even for his enemies. He does not want to think about prison life any more.
However, he is using his experience in prison to bring peace to his village.
"Whenever there is any quarrel or clashes among villagers, I go and try to settle their disputes. Most of them don't know the law.
"I tell them: 'Look at me, a similar violent incident landed me in jail and I only came out after 22 years. Do you want to face the same fate?' Then they sit down for talks."

Monday 26 December 2011

Right-to-buy discounts 'to increase to £50,000'


Housing
Ministers want to boost home ownership and the housing market

Discounts for council tenants wanting to buy their home may be increased to a maximum of £50,000 in England under government proposals.
Most "right-to-buy" discounts are capped - from £16,000 in most of London to £38,000 in parts of the South East.
Plans to raise them is in consultation  as the government seeks to "reinvigorate" the scheme.
Housing Minister Grant Shapps said it would mean right-to-buy was no longer an "empty promise" for many tenants.
But housing charity Shelter has warned that any new scheme must include "rigorous affordability checks" to ensure people can afford to buy and maintain their home.
Plans to raise right-to-buy discounts for tenants in England were announced in the government's housing strategy for england last month and in the chancellor's Autumn Statement.
Council house sales
Ministers say that for every home sold, the government will provide a new "affordable" home, the majority of which are expected to be new builds.
'Miserly' restrictions
Under current rules, council tenants and housing association tenants who were in their home when it was transferred from council landlords have the right to buy their properties at a discount, after five years as a tenant.
The discount can be as much as up to 70 per cent of flats and 60 per cent of houses - depending on the length of time the buyer has been a tenant - but in practice the government says most discounts are limited by caps.
Mr Shapps said the previous "miserly" restrictions on right-to-buy meant the scheme had become an "empty promise" for many tenants.
There were fewer than 3,700 sales last year, compared with 84,000 less than 10 years ago, he added.
The new proposals would "dramatically increase the discounts under right-to-buy, ensuring it once again becomes a meaningful tool to support tenants who want to buy the home they live in", said Mr Shapps.

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George Osborne's mismanagement of the economy is making things worse, holding back house-building”
Jack DromeyShadow housing minister
The plans are part of the government's attempt to boost home ownership as well as the housing market. It has also announced a mortgage indemnity scheme, allowing first-time buyers to borrow up to 95% of the property's value.
'Housing crisis'
On Thursday, the housing minister also outlined details of a £420m fund aimed at getting stalled building schemes, which have planning permission but have been shut down due to a lack of finance, moving.
But Labour says the government has failed to get a grip on the problem.
"With millions in need of a decent home at a price they can afford, the country is gripped by a growing housing crisis," said shadow housing minister Jack Dromey.
"The government's housing policies are failing and George Osborne's mismanagement of the economy is making things worse, holding back housebuilding."
Paul Smee, from the Council of Mortgage Lenders, welcomed the changes in principle and said that under proposals from the Financial Services Authority this week, all tenants seeking a mortgage would have to get advice on lending which would offer "significant protection".
"As with all other mortgages, lenders will need to conform to all relevant regulatory requirements, reflect their own risk appetites and take account of both the borrower's circumstances and whether the property represents adequate security," he said.
The Department for Communities and Local Government is consulting on the proposals until 2 February.